Latest Episodes

Eli Lilly Earnings Call Q4 2025 Recap

This week on On The Pen: The Weekly Dose, Dave breaks down one of the most consequential Eli Lilly earnings calls to date. We dive into major updates on retatrutide, new Phase 3 timelines, and why Lilly is positioning next-generation G...

February 04, 2026 • 21:35

Once Monthly GLP-1 Injection? Pfizer Drops New Data

This week on On The Pen: The Weekly Dose, we break down Pfizer’s $10 billion bet on obesity medicine and whether it’s shaping up to be a smart move or a costly miss. We dig into newly released Phase 2b data from Pfizer’s once-monthly G...

February 03, 2026 • 21:39

A PCOS and Tirzepatide Trial. Finally

Can Zepbound treat PCOS? That's the question this clinical trial will seek to answer, and we cover it exclusively on this week's On The Pen podcast.

January 27, 2026 • 19:29

Over The Counter GLP-1 Prediction

In this episode of On The Pen: The Weekly Dose, Dave Knapp breaks down why the idea of over-the-counter GLP-1 medications isn’t radical speculation, it’s a pattern already in motion. Drawing on FDA signals, past regulatory precedent with Orlist...

January 20, 2026 • 21:02

GLP-1 PLUS Gastric Balloon for added Weight Loss!

Shantanu Gaur, CEO of Allurion, returns to the podcast to break down their swallowable inflatable weight loss balloon, how it works, who it is for, how much it is expected to cost, and when patients can realistically expect access.We ta...

January 19, 2026 • 31:48

Fan Mail

Dave I’ve been following you for about a year now. I just want to thank you for all you do and the true outgoing concern that you show for all of us who struggle with this journey. Thank you especially for the courage to share your own journey with us. I just listened to the most recent podcast with Dr. Nadolsky. I completely understand your difficulty with the decision to have surgery. I’ve been overweight/obese for over 30 years and just could never convince myself that the surgery was a good idea for me. It is a HUGE decision, not just because it is a surgery but also because of the changes it will require in your life. So God bless you for all that you do and your courage to do it to help so many others!

Monroe, Louisiana

Dave Knapp

Host